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Cryo-EM structure of compound 2. The atomic model has been deposited in the Protein Data Bank with the accession code PDB ID 7ZYJ. The 260,000 particles in the best two-dimensional (2D) classes were used for three-dimensional (3D) refinement using C2-symmetry. The resulting refinement of best particles gave rise to a reconstruction with an overall resolution of 2.8 Å.
