Table 3. Predicted and Measured K_p and K_p,uu for Modeling and Follow-Up Set of Compounds^a.

compound	log BB (predicted)	Kp (measured)	fu plasma mouse [%]	fu rat brain [%]	Kp,uu
3	–0.27	0.17	3.0	4.0	0.22
4	0.11	1.2	2.0	1.5	0.90
5	0.23	1.2	0.8	0.6	0.90
6	0.46	1.2	1.2	0.7	0.70
7	0.36	0.61	1.0	0.9	0.55
8	0.10	0.93	5.5	3.0	0.51
9	0.21	0.62	7.3	4.3	0.37
12	–0.05	0.50	4.5	4.0	0.44
13	0.23	1.4	3.9	3.0	1.1
14	0.09	1.1	7.6	4.1	0.59
16	0.08	0.71	2.3	4.3	1.3
17	–0.12	0.34	10.3	8.7	0.28
18	0.06	0.88	8.7	8.8	0.89
19	0.03	1.0	11.8	5.6	0.47
20	0.05	0.85	1.8	1.5	0.71
21	0.00	0.58	4.9	4.6	0.54

^aK_p,uu was calculated using measured K_p, f_u,brain from BTB and f_u,plasma from PPB using the following equation: .