Table 4. Structures of Tested Quinolines and Naphthyridines^a.

compound	T. b. brucei EC50 [nM]	LM CLint M/R/H [μL/min/mg]	MDCK-MDR1 A to B (ER) [10–6 cm/s]
16	37	43/43/<25	7.5 (1.0)
17	94	87/<25/<25	13.2 (0.8)
18	40	151/52/<25	20.0 (0.6)
19	95	51/46/<25	18.2 (0.7)
20	14	588/59/40	9.2 (0.5)
21	53	414/62/55	12.4 (0.6)

^aDetails on the biochemical and cellular assay as well as on clearance (Cl_int) and permeability (MDCK-MDR1) can be found in the Experimental Section.