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. 2022 Aug 26;65(17):11415–11432. doi: 10.1021/acs.jmedchem.2c00573

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© 2022 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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Acriflavine (ACF) strongly changes gene expression. (A, B) Heatmaps of RNA-seq after treatment of HUVECs with ACF. (C) Volcano plot of RNA-seq after treatment of HUVECs with ACF. (D) Chromosomal distribution and percentage of protein-coding genes up- or downregulated with ACF. (E) Correlation analysis of protein-coding genes up- or downregulated with ACF of HUVECs and murine lung endothelial cells. (F) Venn diagram. (G) Number of protein-coding genes up- or downregulated with ACF. (H) GO enrichment analysis with KOBAS2.0. (I) deeptools2: overlaying the RNA-seq reads with the transcription start sites of all genes. Reprinted with permission from ref (11). Copyright 2022 The Authors. Published Open Access by Elsevier under a Creative Commons CC BY license.