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. Author manuscript; available in PMC: 2022 Sep 13.
Published in final edited form as: J Proteome Res. 2021 Oct 21;20(12):5241–5263. doi: 10.1021/acs.jproteome.1c00657

Figure 5: Genome wide associations of circulating protein levels.

Figure 5:

Simplified illustration to depict how genetic variation can influence protein levels. Projecting the results of regression analyses onto the genome can identify regions of genetic variation, so called protein Quantitative Trait Loci (pQTLs), that associate with protein levels. These regions can either localize with the proteins of interest (cis-pQTLs, red) or relate to other regions in the genome (trans-pQTLs, blue).