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Predicted simvastatin lactone (a, b) and acid (c, d) PK profiles in Simcyp (pink/left) and PK‐Sim (blue/right) versus clinical observations reported as study mean (dots) for 40 mg dose (S19–S37). The black line represents the predicted geometric mean and the shaded area represents the predicted 5%–95% quantiles for virtual populations. AUC, area under the curve; Cmax, maximum plasma concentration; Obs, observed; PK, pharmacokinetic; Pred, predicted.
