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Libraries design based on the size/polarity guided triple-code strategy
| Strategy 1: maintain the size and change the polarity | ||||
|---|---|---|---|---|
| Libraries | Wild type | Triple code | ||
| L1 (bulk ring) | F205, Y217, H255, F281 | Y | H | F |
| L2 (long chain) | K254 | R | L | I |
| L3 (short chain) | A252, G283 | S | T | G |
| Strategy 2: maintain the polarity and change the size | ||||
| L4 (hydrophilic) | Y217, K254, H255 | S | H | R |
| L5 (hydrophobic) | F205, A252, F281, G283 | F | V | L |
