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. Author manuscript; available in PMC: 2022 Sep 13.
Published in final edited form as: Nat Med. 2021 Mar 2;27(3):546–559. doi: 10.1038/s41591-020-01227-z

Extended Data Fig. 4. Chromatin accessibility at the ACE2, TMPRSS and CTSL loci across lung cells in early life.

Extended Data Fig. 4.

(a) Schematic: single-cell chromatin accessibility by transposome hypersensitive sites sequencing (THS-Seq) from human pediatric samples (full gestation, no known lung disease) collected at day 1 of life, 14 months, 3 years, and 9 years (n=1 at each time point). (b) Accessibility (dot color log normalized gene activity scores), and % of cells with accessible loci (dot size) for the ACE2, TMPRSS, and CTSL loci (columns) across different cell types (rows) in scTHS-Seq with all time points aggregated. (c) Accessibility (dot color log normalized gene activity scores), and % of cells with accessible loci (dot size) of ACE2, TMPRSS and CTSL in AT1--AT2 cells in scTHS-Seq at day 1 of life, 14 months, 3 years, and 9 years (rows). (d) Number of ACE2+CTSL+ and ACE2+TMPRSS2+ cells per time point.