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. Author manuscript; available in PMC: 2022 Sep 13.
Published in final edited form as: Sci Transl Med. 2021 Jan 13;13(576):eabc0227. doi: 10.1126/scitranslmed.abc0227

Figure 2. Dynamics of CD8+ T cell trafficking into GVHD-target organs following HCT in NHP.

Figure 2.

(A) Mononuclear cells were isolated from different organs from HC animals (n=4) or from recipient animals on day +8 following auto-HCT (n=4 animals) or MAMU-A001-mismatched allo-HCT (n=3 animals). A representative gating tree depicts SIVS-based measurement of donor and host CD8+ T cell migration in MAMU-A001-mismatched allo-HCT transplantation. (B-D) Plots, depicting relative migration of donor and host CD8+ T cells from MAMU-A001-mismatched allo-HCT recipients, normalized to the migration of CD8+ T cells in untransplanted HC animals (B); relative migration of CD8+ T cells from autologous HCT recipients, normalized to the migration of CD8+ T cells in untransplanted HC (C) and relative migration of donor and host CD8+ T cells from MAMU-A001-mismatched allo-HCT recipients, normalized to the migration of CD8+ T cells following auto-HCT (D). pLN – peripheral Lymph Nodes, medLN – mediastinal Lymph Nodes, mesLN – mesenteric Lymph Nodes. *p<0.05 using t-test with Holm-Sidak multiple comparison correction.