TABLE 1.
Group Statistics for Outcomes of Patients on Renin-Angiotensin-Aldosterone System Inhibitors Only, Renin-Angiotensin-Aldosterone System Inhibitors and Other Antihypertensive Agents and Other Antihypertensive Agents Only
| Outcomes | RAASIs Only (N = 1,542) | RAASIs and Other AHAs (N = 2,668) | Other AHAs Only (N = 3,765) | p | |||
|---|---|---|---|---|---|---|---|
| Analysis of Variance | RAASIs Only vs Both Medications | Both Medications vs Other AHAs Only | RAASIs vs Other AHAs Only | ||||
| In-hospital mortality, n (%) | 286 (18.5) | 640 (24.0) | 884 (23.5) | < 0.0001 | < 0.0001 | 0.66 | < 0.0001 |
| Use of CRRT/hemodialysis, n (%) | 66 (4.2) | 207 (7.5) | 230 (5.9) | < 0.0001 | < 0.0001 | 0.013 | 0.012 |
| Time on CRRT (d), mean ± sd | 10.0 ± 9.3 | 9.4 ± 10.1 | 10.7 ± 11.5 | 0.42 | 0.63 | 0.20 | 0.60 |
| Use of extracorporeal membrane oxygenation, n (%) | 19 (1.2) | 24 (0.9) | 27 (0.7) | 0.19 | 0.38 | 0.50 | 0.094 |
| Admitted to ICU, n (%) | 713 (46.4) | 1,241 (47.1) | 1,669 (46.9) | 0.92 | 0.71 | 0.93 | 0.77 |
| ICU length of stay (d), mean ± sd | 14.3 ± 15.3 | 12.7 ± 12.8 | 12.0 ± 12.7 | < 0.0001 | < 0.0001 | 0.0003 | < 0.0001 |
| Hospital length of stay (d), mean ± sd | 15.9 ± 19.7 | 15.1 ± 14.3 | 15.0 ± 16.7 | 0.0011 | 0.0027 | 0.56 | 0.0007 |
| Use of mechanical ventilation, n (%) | 424 (27.5) | 786 (29.5) | 1,004 (26.7) | 0.046 | 0.19 | 0.015 | 0.56 |
| Time on ventilator (d), mean ± sd | 14.9 ± 14.8 | 13.1 ± 12.1 | 13.2 ± 14.9 | 0.072 | 0.024 | 0.87 | 0.052 |
| Complications during hospitalization, n (%) | |||||||
| Respiratory failure (acute respiratory distress syndrome) | 320 (20.8) | 576 (21.6) | 729 (19.4) | 0.085 | 0.55 | 0.031 | 0.26 |
| Mild (P:F 200–300) | 21 (8.1) | 60 (12.5) | 62 (10.5) | 0.31 | 0.10 | 0.60 | 0.32 |
| Moderate (P:F 100–199) | 73 (28.1) | 146 (30.4) | 181 (30.7) | ||||
| Severe (P:F < 100) | 166 (63.8) | 275 (57.2) | 347 (58.8) | ||||
| Septic shock | 170 (11.0) | 355 (13.3) | 435 (11.6) | 0.041 | 0.035 | 0.038 | 0.61 |
| Congestive heart failure | 24 (1.6) | 93 (3.5) | 116 (3.1) | 0.0012 | 0.0004 | 0.41 | 0.0023 |
| Cardiac arrhythmia | 78 (5.1) | 202 (7.6) | 232 (6.2) | 0.0040 | 0.0020 | 0.030 | 0.14 |
| Stroke | 15 (1.0) | 47 (1.8) | 39 (1.0) | 0.019 | 0.056 | 0.017 | 0.95 |
| Co- or secondary infection | 66 (4.3) | 139 (5.2) | 156 (4.1) | 0.11 | 0.20 | 0.051 | 0.88 |
AHAs = antihypertensive agents, CRRT = continuous renal replacement therapy, P:F = Pao2:Fio2 ratio, RAASIs = renin-angiotensin-aldosterone system inhibitors.
Boldface values indicate statistical significance.