Table 3.

Univariable and Multivariable Analysis for 2-Year Freedom from Driveline Infection (N = 590^*)

	Univariate HR (95% CI)	P value	Multivariate HR (95% CI)	P value
E2 vs. E1	0.35 (0.20–0.62)	0.0003	0.36 (0.20–0.64)	0.0006
E3 vs. E2	0.86 (0.40–1.87)	0.7046	0.89 (0.41–1.95)	0.7731
E4 vs. E2	1.04 (0.52–2.07)	0.9130	1.01 (0.51–2.01)	0.9847
Age, years	0.99 (0.97–1.01)	0.1650	1.00 (0.98–1.01)	0.8053
Male	0.55 (0.33–0.94)	0.0280	0.59 (0.46–1.30)	0.0578
BMI ≥30	0.90 (0.52–1.55)	0.6920
Diabetes mellitus	0.81 (0.49–1.33)	0.4040
Etiology, Ischemic	0.69 (0.42–1.13)	0.1380	0.77 (0.46–1.30)	0.3226
INTERMACS profile ≤2	1.16 (0.68–1.99)	0.5790
Device intent, DT	1.35 (0.84–2.19)	0.2170
Serum creatinine, mg/dL	0.92 (0.62–1.36)	0.6750
Serum albumin, g/dL	1.39 (0.92–2.11)	0.1220	1.37 (0.89–2.10)	0.1510
WBC (1000/μL)	0.98 (0.92–1.05)	0.5760
Pump type (HMII vs. HM3)	1.19 (0.70–2.03)	0.5280
Pump type (HVAD vs. HM3)	0.65 (0.22–1.90)	0.4270

^*One patient died the day of implant and was excluded from this analysis. Further, three patients did not have serum albumin data, being excluded from the albumin-only model and multivariate model (N = 587).

E1, Era 1; E2, Era 2; E3, Era 3, E4, Era 4; BMI, body mass index; INTERMACS, Interagency Registry for Mechanically Assisted Circulatory Support; DT, destination therapy; WBC, white blood cell count; HM3, HeartMate 3; HVAD, HeartWare; HMII, HeartMate II; DLI, driveline infection.