Table 3. Effect of maternal and prepubertal codeine use, and prepubertal arginine use on fertility indices.

	Fertility success (%)	Fertility index (%)
Control	90	100
Codeine	40	70
Arginine	100	100
Codeine + Arginine	80	90
Control +	70	90
Codeine +	20	50
Arginine +	100	100
Codeine + Arginine +	90	100

⁺ Offsprings of dams exposed to codeine

Data are expressed as mean±SD for ten rats per group and analyzed by unpaired T-test

^aP < 0.05 vs control of same cohort, ^bP < 0.05 vs codeine of same cohort

^cP < 0.05 vs arginine of same cohort, ^dP < 0.05 vs control without maternal codeine exposure

^eP < 0.05 vs same prepubertal treatment without maternal codeine exposure