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. 2022 Sep 13;17(9):e0274403. doi: 10.1371/journal.pone.0274403

Table 6. Synthesis of evidence, risk of bias judgements and quality of evidence scores for the impact of clinical pain on individual task performance outcome measures.

Outcome Measure Studies Motor learning paradigm D1 D2 D3 D4 D5 D6 D7 Overall Risk of bias Impact of pain Quality of evidence
Acquisition Phase
Accuracy–temporal/spatial error from actual trace Andrew (2018) [46] Visuomotor task S L L L L M L Serious NC Very low
Accuracy Parker (2017) [42] Repeated ballistic movements S L L L L M L Serious + Very low
Acceleration Vallence (2013) [43] Repeated ballistic movements S L L L L M L Serious - Very low
Time to target Brown (2022) [44] Explicit Motor sequence task M L L L L M L Moderate NC Low
Time to target Brown (2022) [44] Implicit Motor sequence task M L L L L M L Moderate NC Low
Distance hand moved Brown (2022) [44] Explicit Motor sequence task M L L L L M L Moderate NC Low
Distance hand moved Brown (2022) [44] Implicit Motor sequence task M L L L L M L Moderate NC Low
Movement error Dupuis (2022) [45] Motor Adaptation M L L L L M L Moderate NC Low
Timing of errors Dupuis (2022) [45] Motor Adaptation M L L L L M L Moderate NC Low
Retention/consolidation
Accuracy–temporal/spatial error from actual trace Andrew (2018) [46] Visuomotor task S L L L L M L Serious - Very low
Time to target Brown (2022) [44] Explicit Motor sequence task M L L L L M L Moderate NC Low
Time to target Brown (2022) [44] Implicit Motor sequence task M L L L L M L Moderate NC Low
Distance hand moved Brown (2022) [44] Explicit Motor sequence task M L L L L M L Moderate NC Low
Distance hand moved Brown (2022) [44] Implicit Motor sequence task M L L L L M L Moderate NC Low
Movement error Dupuis (20220) [45] Motor Adaptation M L L L L M L Moderate NC Low
Timing of errors Dupuis (2022) [45] Motor Adaptation M L L L L M L Moderate NC Low

Abbreviations: NC, No change in task performance; -, Pain caused a reduction in task performance; +, Pain caused an increase in task performance; Risk of bias: L = Low, M = Medium S = Serious, C = Critical.