Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 18;226(5):833–842. doi: 10.1093/infdis/jiaa512

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 5. — CD8^+/ΔTCR T cells transduced with Epstein-Barr virus Latent Membrane Protein 2 ESEERPPTPY (EBV-LMP2^ESE)–specific T-cell receptors (TCRs) lyse target cells presenting endogenous LMP2 peptide. A, Representative examples are shown of CD8^+/ΔTCR T cells transduced with EBV-LMP2^ESE–specific TCRs that were tested for their lytic capacity against malignant cells transduced with HLA-A*01:01 and LMP2 or against HLA-A*01:01–positive or –negative EBV-transformed lymphoblastoid cell lines (LCLs). CD8^+/ΔTCR T cells transduced with a TCR targeting HLA-A*02:01/cytomegalovirus (CMV)–pp65^NLV were used as control. B, Primary CD8^+/ΔTCR T cells transduced with EBV-LMP2^ESE–specific TCR-C1 were tested for their lytic capacity against 2 HLA-A*01:01–transduced subclones of the malignant Burkitt lymphoma cell line mutu-III. Mutu-III subclone c148 expressed LMP2 >100-fold higher compared to subclone c176. CD8^+/ΔTCR T cells transduced with a TCR targeting HLA-A*02:01/CMV-pp65^NLV were used as negative control. Data are shown from 1 experiment carried out in triplicate. Abbreviations: td; transduced, E:T, Effector:Target.