Table 2.
Antagonists of CCL2 and CCR2.
| Drug | Target | Conditions | Stage | NCT number/References |
|---|---|---|---|---|
| Nox-E36 | CCL2 | Type 2 Diabetes Mellitus (T2DM) Renal Impairment Chronic Inflammatory Diseases Systemic Lupus Erythematosus |
I/II |
NCT01547897 NCT01372124 NCT00976729 |
| AZD-2423 | CCR2 | Chronic Obstructive Pulmonary Disease (COPD) Nerve Pain |
II |
NCT01215279 NCT01200524 |
| BMS-687681 | CCR2, CCR5 | Pancreatic ductal adenocarcinoma | Pre | (84) |
| BMS-741672 | CCR2 | T2DM Neuropathic Pain |
II |
NCT00699790 NCT00683423 |
| BMS-813160 | CCR2, CCR5 | Diabetic Kidney Disease Colorectal Cancer, Pancreatic Cancer Lung Cancer, Hepatocellular Carcinoma |
I/II |
NCT01752985 NCT03184870 NCT04123379 |
| CCX140-B | CCR2 | Glomerulosclerosis Diabetic Nephropathy, T2DM |
II |
NCT03536754 NCT01447147 |
| CCX872-B | CCR2 | Pancreatic Cancer | I/II |
NCT03778879 NCT02345408 |
| Cenicriviroc | CCR2, CCR5 | Primary Sclerosing Cholangitis Prediabetic State, T2DM HIV Non-alcoholic Steatohepatitis (NASH) COVID 19 |
I/II/III |
NCT02653625 NCT02330549 NCT01827540 NCT03517540 NCT04593940 |
| CNTX-6970 | CCR2 | Chronic Pain, Nociceptive Pain Knee Osteoarthritis |
I/II |
NCT03787004 NCT05025787 |
| GSK1344386B | CCR2 | Atherosclerosis | Pre | (85) |
| INCB-3284 | CCR2 | Rheumatoid Arthritis (RA), T2DM | I/II | (86, 87) |
| INCB-3344 | CCR2 | Atherosclerosis, Diabetic nephropathy Chronic inflammatory diseases |
Pre | (88–90) |
| INCB-8696 | CCR2 | Multiple sclerosis (MS), Lupus | I | (86) |
| INCB-8761 | CCR2 | Metastatic Pancreatic Ductal Adenocarcinoma Osteoarthritis Chronic Hepatitis C |
II |
NCT02732938 NCT00689273 NCT01226797 |
| JNJ-17166864 | CCR2 | Allergic Rhinitis | II | NCT00604123 |
| JNJ-27141491 | CCR2 | MS | Pre | (91) |
| JNJ-41443532 | CCR2 | T2DM | II | NCT01230749 |
| MK-0812 | CCR2 | MS Arthritis, Rheumatoid |
II |
NCT00239655 NCT00542022 |
| PF-04634817 | CCR2, CCR5 | Renal Insufficiency Diabetic Nephropathy Macular Edema, Diabetic |
I/II |
NCT01791855 NCT01712061 NCT01994291 |
| PQ50 | CCR2 | Critical Limb Ischemia | II | NCT01232673 |
| RAP-103 | CCR2, CCR5, CCR8 | Diabetic neuropathic pain | Pre | (92, 93) |
| RO5234444 | CCR2 | T2DM | Pre | (94) |
| RS102895 | CCR2, Human ADRA1A, Human ADRA1D, Rat HTR1A |
Diabetic nephropathy, Ischemia/reperfusion injury, Hypertension |
Pre | (95–97) |
| RS504393 | CCR2, Human ADRA1A, Human ADRA1D, Rat HTR1A | Hypertension, Cardiac Hypertrophy Pain |
Pre | (31, 98, 99) |
| SSR150106 | CCR2 | RA | II | NCT00545454 |
| TLK-19705 | CCR2, CCR5 | Atherosclerosis | Pre | (100) |
Diabetic nephropathy is one of the most important comorbidities in diabetic patients.