Table 5.
Toxicity prediction of potential lead compounds using Protox-II
| Compound name | LD50 mg/Kg | Toxicity class | Predicted active targets | Probability |
|---|---|---|---|---|
| Quercitrin | 5000 | 5 |
Carcinogenicity Immunotoxicity Aryl hydrocarbon receptor |
0.50 0.97 0.55 |
| Teucrol | 5000 | 5 |
Immunotoxicity Estrogen receptor ligand-binding domain Phosphoprotein (tumor supressor) p53 ATPase family AAA domain-containing protein 5 |
0.68 0.84 0.85 0.77 |
| Malvinidin-3-arabinoside | 5000 | 5 |
Immunotoxicity Cytotoxicity |
0.99 0.50 |
| N-E-caffeoyl tyramine | 500 | 4 | Immunotoxicity | 0.64 |
| ZINC000085967772 | 5000 | 5 |
Carcinogenicity Immunotoxicity |
0.51 0.97 |
| Pinobanksin 3-(E)-caffeate | 2000 | 4 |
Carcinogenicity Immunotoxicity |
0.55 0.97 |
| Abyssinone IV | 2000 | 4 |
Immunotoxicity Mitochondrial membrane potential |
0.88 0.69 |