Table 2.

Bidirectional MR results for LST and MVPA during leisure time with BMI or body fat percentage using genome-wide summary results (CAUSE method)

Exposure	Outcome	Gammaa	95% CI	P valueb	Exposure	Outcome	Gammaa	95% CI	P valueb
LST	Body fat %	0.18	0.13 to 0.24	1.8 × 10−3	LST	BMI	0.31	0.28 to 0.35	6.7 × 10−28
Body fat %	LST	0.12	0.04 to 0.18	0.14	BMI	LST	0.18	0.16 to 0.19	1.1 × 10−14
MVPA	Body fat %	−0.12	−0.20 to −0.04	0.07	MVPA	BMI	−0.14	−0.20 to −0.07	6.0 x 10−3
Body fat %	MVPA	−0.03	−0.09 to 0.02	0.53	BMI	MVPA	−0.09	−0.11 to −0.06	7.4 x 10−3
LST	Comparative height at age 10	0.03	0.01 to 0.04	0.04	LST	Comparative body size at age 10	0.02	0.01 to 0.03	0.04

^aPosterior median of gamma, which can be taken as a point estimate of the causal effect. This estimate tends to be shrunk slightly toward zero compared with other methods. ^bThe P value for comparing the causal model with the sharing model. P < 0.05 indicates that posteriors estimated under the causal model predict the data significantly better than posteriors estimated under the sharing model.