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. 2022 Aug 18;54(9):1355–1363. doi: 10.1038/s41588-022-01154-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a) Overlaps between trans-sGenes, cis-sGenes, and trans-eGenes. b) Overlap of the trait-associated trans-sGenes and trans-eGenes identified by SMR & COLOC PP4. c) Association of SYTL2 with major depression (MD) through both the trans-sQTLs and trans-eQTLs. The top track shows −log10(p-values) of SNPs from the MD GWAS. The second and third tracks show −log10(p-values) from the THISTLE trans-sQTL and trans-eQTL analyses, respectively, for SYTL2. d) Manhattan plot of p-values from genome-wide THISTLE sQTL analysis for SYTL2. The blue arrow indicates the genomic position where SYTL2 is located. The GWAS and eQTL p-values in panel c were computed using a one-sided chi-squared test, and the THISTLE sQTL p-values in panels c and d were computed using a one-sided sum of chi-squared test.