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. 2022 Aug 18;54(9):1355–1363. doi: 10.1038/s41588-022-01154-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Overlap between sGenes and eGenes. b, COLOC PP3 and PP4 values between the cis-sQTL and cis-eQTL signals and LD r² between the lead cis-sQTL and cis-eQTL SNPs for the 9,389 overlapping genes. The line inside each box indicates the median value, the notches indicate the 95% confidence interval (CI), the central box indicates the interquartile range (IQR) and the whiskers indicate data up to 1.5 times the IQR. c, The number of sGenes (or eGenes) discovered as a function of sample size. d, The number of sQTLs (or eQTLs) discovered as a function of sample size. e, The overlap between sGenes and eGenes (or between sQTLs and eQTLs) as a function of sample size, where sQTL–eQTL overlap is defined as the proportion of sGenes for which the lead sQTL SNP is a significant eQTL SNP for the same gene.

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