Extended Data Fig. 1. Comparison of statistical power between THISTLE and sQTLseekeR by simulation with transcription abundances generated from a multivariate distribution.
Transcription abundance was simulated from either a multivariate normal distribution (panels a and c) or a multivariate Poisson distribution (panels b and d) with (scenario 4) or without an eQTL effect (scenario 3) in a sample of 500 unrelated individuals (Section 2 of the Supplementary Note). The THISTLE and sQTLseekeR p-values were computed from a one-sided sum of chi-squared test (approximated by the Saddlepoint algorithm) and pseudo-F test (approximated by the Davies algorithm), respectively.