Table 2.
Association between self-reported and metabolomic adiposity scores & breast cancer incidence for women premenopausal at blood draw.a
| Premenopausal at blood draw | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Adiposity measures | Quartile 1b | Quartile 2b | Quartile 3b | Quartile 4b | |||||
| Self-reported | N cases/controls | OR (95% CI) | N cases/controls | OR (95% CI) | N cases/controls | OR (95% CI) | N cases/controls | OR (95% CI) | P-trendc |
| BMI (kg/m2) | 270/262 | 1.0 (ref) | 225/197 | 1.20 (0.92–1.57) | 179/180 | 1.11 (0.83–1.49) | 152/181 | 0.96 (0.68–1.35) | 0.69 |
| Waist circumference (cm) | 134/141 | 1.0 (ref) | 183/152 | 1.29 (0.92–1.79) | 111/124 | 0.91 (0.63–1.32) | 80/82 | 1.06 (0.68–1.66) | 0.83 |
| Weight change (kg) | 220/210 | 1.0 (ref) | 251/253 | 0.91 (0.69–1.19) | 194/191 | 0.95 (0.71–1.26) | 158/169 | 0.89 (0.66–1.21) | 0.54 |
| Fat mass | 176/171 | 1.0 (ref) | 141/108 | 1.33 (0.94–1.87) | 83/107 | 0.78 (0.53–1.14) | 98/99 | 0.97 (0.64–1.47) | 0.04 |
| Metabolomic score | |||||||||
| BMI (kg/m2) | 256/217 | 1.0 (ref) | 227/217 | 0.91 (0.70–1.19) | 176/203 | 0.79 (0.60–1.05) | 167/183 | 0.82 (0.61–1.12) | 0.14 |
| Waist circumference (cm) | 144/132 | 1.0 (ref) | 149/126 | 1.12 (0.79–1.59) | 111/130 | 0.78 (0.54–1.12) | 104/111 | 0.90 (0.62–1.32) | 0.27 |
| Weight change (kg) | 251/233 | 1.0 (ref) | 230/204 | 1.08 (0.83–1.41) | 177/190 | 0.91 (0.69–1.20) | 165/196 | 0.83 (0.62–1.11) | 0.14 |
| Fat mass | 150/123 | 1.0 (ref) | 141/128 | 0.92 (0.65–1.30) | 96/123 | 0.65 (0.45–0.94) | 111/111 | 0.83 (0.57–1.21) | 0.15 |
| Premenopausal at blood draw and at diagnosis | |||||||||
| BMI (kg/m2) | 158/148 | 1.0 (ref) | 119/111 | 1.01 (0.71–1.44) | 98/99 | 0.92 (0.62–1.36) | 73/91 | 0.69 (0.43–1.11) | 0.12 |
| Waist circumference (cm) | 79/79 | 1.0 (ref) | 100/75 | 1.31 (0.83–2.07) | 62/65 | 0.86 (0.52–1.42) | 39/45 | 0.77 (0.42–1.42) | 0.23 |
| Weight change (kg) | 126/122 | 1.0 (ref) | 141/141 | 0.92 (0.64–1.32) | 103/102 | 0.94 (0.64–1.38) | 75/83 | 0.80 (0.53–1.22) | 0.34 |
| Fat mass | 112/85 | 1.0 (ref) | 69/60 | 0.79 (0.49–1.26) | 45/55 | 0.52 (0.31–0.88) | 48/54 | 0.52 (0.29–0.92) | 0.04 |
| Metabolomic score | |||||||||
| BMI (kg/m2) | 146/131 | 1.0 (ref) | 124/121 | 0.94 (0.66–1.35) | 97/108 | 0.81 (0.56–1.18) | 81/89 | 0.78 (0.52–1.19) | 0.19 |
| Waist circumference (cm) | 83/77 | 1.0 (ref) | 85/67 | 1.18 (0.74–1.88) | 62/63 | 0.85 (0.52–1.38) | 50/57 | 0.79 (0.47–1.33) | 0.23 |
| Weight change (kg) | 143/140 | 1.0 (ref) | 124/109 | 1.17 (0.82–1.68) | 91/107 | 0.86 (0.59–1.25) | 87/92 | 0.90 (0.61–1.35) | 0.39 |
| Fat mass | 88/70 | 1.0 (ref) | 78/65 | 0.94 (0.58–1.51) | 54/61 | 0.67 (0.40–1.12) | 54/58 | 0.67 (0.39–1.12) | 0.07 |
aMultivariable logistic regression models adjusted for age at menarche, age at first birth and parity combined, breastfeeding history, history of benign breast disease, family history of breast cancer, BMI at age 18 (kg/m2), alcohol use (g/day) at blood draw, and activity level (MET-h/week) at blood draw, oral contraceptive use at blood draw, and matched factors (age, fasting status, and month of blood draw).
bQuartile values were determined from the full cohort (pre-and postmenopausal at blood draw) for each measure. See Supplemental Table 3 for values.
cP-trend calculated using the median of quartiles (defined by the overall cohort).