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. 2022 Jun 17;127(6):1014–1025. doi: 10.1038/s41416-022-01878-4

Fig. 1. F1-7 inhibiting phosphorylation of FGFR in colon cancer.

Fig. 1

a The chemical structure of F1-7. b Inhibition of FGFR kinase activity in biochemical assays. c IC50 values of F1-7 in colon cancer cells. Cell lines were seeded in 96-well plate and treated with various concentrations of F1-7. Proliferation was measured after 48 h of treatment by the MTT assay. Data are expressed as the mean ± SD of three independent experiments. d Cells were incubated with F1-7 at different concentrations for 24 h, cell lysates were collected for western blot analysis to determine protein expression of FGFR signaling pathway, GAPDH was used as loading control.