Fig. 4. CCL23-induced T-cell signalling.
a Phosphoprotein array of CCL23-treated T cells. The experiment was performed once. b Increased GSK3b phosphorylation induced by CCL23. The experiment was performed once. c Validation and quantification of phosphorylation of GSK3β and Akt by western blot. The experiment was performed once each. d GSK3 inhibition reduces the expression of exhaustion markers on CD8 + T cells. The experiment was replicated with n = 3 donors. Statistical analysis was conducted by one-way ANOVA (*P < 0.05; **P < 0.005; ***P < 0.001; ****P < 0.0001).