Table 3.
Association between pre-diagnosis and post-diagnosis EDIP score and mortality among women with ovarian cancer by histotype, NHS and NHSII.
| Ovarian cancer-specific mortality | All-cause mortality | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| High-grade serous or poorly differentiated histology | Non-serous or low-grade serous histology | High-grade serous or poorly differentiated histology | Non-serous or low-grade serous histology | |||||||||||
| Total cases, n | Deaths, n | HR (95% CI) | Total cases, n | Deaths, n | HR (95% CI) | p-het | Total cases, n | Deaths, n | HR (95% CI) | Total cases, n | Deaths, n | HR (95% CI) | p-het | |
| Pre-diagnosis EDIP score | ||||||||||||||
| Quintile 1 | 140 | 102 | ref | 57 | 23 | ref | 0.40 | 140 | 110 | ref | 57 | 29 | ref | 0.14 |
| Quintile 2 | 145 | 102 | 0.83 (0.63–1.10) | 53 | 21 | 1.20 (0.64–2.24) | 145 | 114 | 0.84 (0.64–1.09) | 53 | 28 | 1.45 (0.84–2.51) | ||
| Quintile 3 | 134 | 97 | 0.88 (0.66–1.16) | 61 | 21 | 0.87 (0.47–1.59) | 134 | 107 | 0.89 (0.68–1.16) | 61 | 29 | 1.03 (0.61–1.75) | ||
| Quintile 4 | 137 | 93 | 0.91 (0.68–1.21) | 54 | 20 | 1.25 (0.67–2.34) | 137 | 104 | 0.93 (0.70–1.23) | 54 | 32 | 1.53 (0.90–2.60) | ||
| Quintile 5 | 108 | 70 | 0.78 (0.57–1.07) | 85 | 34 | 1.17 (0.65–2.11) | 108 | 77 | 0.77 (0.57–1.04) | 85 | 41 | 1.11 (0.65–1.90) | ||
| p-trend | – | – | 0.26 | – | – | 0.64 | – | – | – | 0.24 | – | – | 0.67 | – |
| Post-diagnosis EDIP score | ||||||||||||||
| Quintile 1 | 101 | 59 | ref | 53 | 13 | ref | 0.97 | 101 | 70 | ref | 53 | 19 | ref | 0.33 |
| Quintile 2 | 105 | 67 | 1.03 (0.71–1.47) | 47 | 10 | 1.42 (0.59–3.40) | 105 | 77 | 0.95 (0.68–1.33) | 47 | 19 | 2.20 (1.13–4.31) | ||
| Quintile 3 | 110 | 67 | 1.29 (0.90–1.85) | 42 | 15 | 1.59 (0.74–3.44) | 110 | 74 | 1.17 (0.83–1.63) | 42 | 23 | 1.91(1.02–3.55) | ||
| Quintile 4 | 103 | 69 | 1.22 (0.85–1.75) | 52 | 11 | 1.25 (0.53–2.97) | 103 | 78 | 1.12 (0.80–1.57) | 52 | 25 | 2.05 (1.07–3.90) | ||
| Quintile 5 | 88 | 61 | 1.23 (0.85–1.76) | 65 | 19 | 1.77 (0.79–3.96) | 88 | 68 | 1.15 (0.82–1.61) | 65 | 31 | 1.95 (1.04–3.67) | ||
| p-trend | – | – | 0.15 | – | – | 0.24 | – | – | – | 0.24 | – | – | 0.06 | – |
Non-serous histology subtype refers to mucinous, endometrioid, clear cell, transitional/Brenner, or mixed subtypes of ovarian cancer.
Pre-diagnosis diet is the cumulative average of the dietary scores up to 1 cycle prior to diagnosis. Post-diagnosis diet was assessed 1–4 years after diagnosis.
Models adjusted for age at diagnosis, calendar year at diagnosis, histology, stage, smoking status, body mass index (<25, 25–29, 30 + ), total energy intake. Post-diagnosis model additionally adjusted for nonsteroidal anti-inflammatory drug (NSAID) use, which include aspirin and non-aspirin NSAID use.
AHEI alternative healthy eating index, CI confidence interval, EDIP empirical dietary inflammatory pattern score, HR hazard ratio, NHS Nurses’ Health Study, NHSII Nurses’ Health Study II, p-het p-heterogeneity.