Table 1.
Immunohistological protein expression characteristics of eight MelaGenix®-relevant genes in cutaneous melanomas and adjacent stroma
| Antibody | Stained cell type | Stained cell compartment | Staining localization | Other stained structures/cell types | Other characteristics |
|---|---|---|---|---|---|
| COL6α6 | Melanocytes | Cytoplasm | Epidermis, dermis | Glands, connective tissue | |
| DCD | Melanocytes | Cytoplasm | Epidermis, dermis | Glands | Overall very low expression |
| GBP4 | Melanocytes, keratinocytes | Cytoplasm | Epidermis, dermis | Glands, connective tissue | |
| KLHL41 | Melanocytes, keratinocytes | Cytoplasm, partly membranous staining in epidermis | Epidermis, dermis | Glands, connective tissue, blood vessels | More intense staining than the others but partly diffuse |
| KRT9 | Melanocytes, keratinocytes | Membranous, cytoplasm in part | Dermal melanocytes; keratinocytes (horny layer to spinous layer) | Glands | Much more staining in keratinocytes than in melanocytes |
| PIP | Melanocytes, keratinocytes | In melanocytes nuclear and cytoplasmic staining, keratinocytes rather nuclear staining | Epidermis, dermis | Glands | |
| SCGB1D2 | Melanocytes | Cytoplasm, partly membranous staining | Dermis | Glands | |
| SCGB2A2 | Melanocytes, keratinocytes | Cytoplasm of melanocytes; Nuclear staining in epidermal keratinocytes | Epidermis, dermis | Glands |