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. 2022 May 11;148(10):2723–2742. doi: 10.1007/s00432-022-04019-9

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Fig. 2 — Graphical presentation of KRAS_mut, PIK3CA_mut, BRAF_mut, and MMR status in CRC cases from the NLCS. a Pie chart showing the distribution of the all-wild-type + pMMR and any-mutation/dMMR subgroups (based on all CRC cases; n = 1934). b Bar chart showing frequencies of KRAS_mut, PIK3CA_mut, BRAF_mut, and dMMR (based on all CRC cases; n = 1934). c Venn diagram showing combinations of KRAS_mut, PIK3CA_mut, BRAF_mut, and dMMR (based on any-mutation/dMMR subgroup; n = 1142). The color intensity indicates the frequency: a darker color indicates more cases; a lighter color indicates fewer cases. d/pMMR mismatch repair deficiency/proficiency; mut mutation; CRC colorectal cancer; NLCS Netherlands Cohort Study