Table 1.
Frequenciesa [n (%)] of subgroups based on mutation and MMR status in CRC cases, by tumor location and sex; NLCS, 1986–2006
| CRC | pd | Colon | Rectum | pe | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total n = 1934 |
Men n = 1113 |
Women n = 821 |
Total n = 1384 |
Men n = 754 |
Women n = 630 |
Total n = 355 |
Men n = 224 |
Women n = 131 |
|||
| All-wild-type + pMMRb | 792 (41.0) | 516 (46.4) | 276 (33.6) | < 0.001 | 488 (35.3) | 309 (41.0) | 179 (28.4) | 199 (56.1) | 135 (60.3) | 64 (48.9) | < 0.001 |
| Any-mutation/dMMRc | 1142 (59.1) | 597 (53.6) | 545 (66.4) | 896 (64.7) | 445 (59.0) | 451 (71.6) | 156 (43.9) | 89 (39.7) | 67 (51.2) | ||
| KRASmut | 673 (34.8) | 376 (33.8) | 297 (36.2) | 0.275 | 478 (34.5) | 256 (34.0) | 222 (35.2) | 123 (34.7) | 68 (30.4) | 55 (42.0) | 0.969 |
| PIK3CAmut | 334 (17.3) | 196 (17.6) | 138 (16.8) | 0.645 | 266 (19.2) | 150 (19.9) | 116 (18.4) | 45 (12.7) | 30 (13.4) | 15 (11.5) | 0.004 |
| BRAFmut | 298 (15.4) | 117 (10.5) | 181 (22.1) | < 0.001 | 278 (20.1) | 105 (13.9) | 173 (27.5) | 14 (3.9) | 8 (3.6) | 6 (4.6) | < 0.001 |
| dMMR | 206 (10.7) | 72 (6.5) | 134 (16.3) | < 0.001 | 201 (14.5) | 70 (9.3) | 131 (20.8) | 3 (0.9) | 1 (0.5) | 2 (1.5) | < 0.001 |
(d/p)MMR mismatch repair (deficient/proficient); CRC colorectal cancer; NLCS Netherlands Cohort Study; mut mutated
aPercentages might not add up because multiple molecular characteristics (e.g. BRAF mutation and MMR deficiency) can occur per individual
bThis group excludes cases with mutations in any of the genes (KRAS, PIK3CA, or BRAF), as well as MMR deficient cases
cThis group includes cases with mutations in any of the genes (KRAS, PIK3CA, or BRAF) and/or cases that are MMR deficient
dDifference between men and women, based on total CRC, evaluated using Chi-square
eDifference between colon and rectum, based on men and women combined, evaluated using Chi-square