Fig. 3.

Mechanisms of double minute generation through chromothripsis. a Chromothripsis is caused by lagging chromosome micronucleation. Often, a derivative chromosome is formed in this process. b Breakage-fusion-bridge cycles can result in generation of double minutes when a chromosome bridge is shattered. Here, there are two possible scenarios. A micronucleus-independent process, where the damage occurring at the site of the bridge breakage leads to double minute generation. Alternatively, micronucleation could precede double minute formation