Table 1.

Summary of IL-17 family members and their cognate receptors

Family member	Functions	Receptor
IL-17A	•Protection against bacterial and fungal infection •Pro-inflammatory function in immune-mediated diseases •Regulation of Th17 cell function and migration •Mucosal integrity	IL-17RA, IL-17RC, IL-17RD
IL-17B	•Immune-mediated arthritis in mouse model of disease •Anti-inflammatory role in the colon antagonizing the gut-inflammatory action of Il-17E	IL-17RB
IL-17C	•Inflammatory response to infection and immune-mediated disease •Upregulated early as compared to IL-17A •Autocrine potentiation of Th17 cell response	IL-17A, IL-17-RE
IL-17D	•Increased production of inflammatory cytokines in endothelial cells •Protective effect in experimental colitis in mice •Promotes natural killer cell targeting of tumour cells	CD93
IL-17E	•Promote the allergic response in Th2 and mast cells	IL-17RA, IL-17RB
IL-17F	•Similar to IL-17A signalling, can form heterodimers with IL-17A and bind to common receptors	IL-17RA, IL-17RC, Il-17-RD