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. 2022 Sep 13;13:5347. doi: 10.1038/s41467-022-32928-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Analysis of publicly available MPN RNA-seq dataset²¹. Left Panel: Expression levels of IL1A mRNA in granulocytes of heathy controls (HC) (n = 23) and MPN patients with JAK2V617F (n = 62), CLAR Type I (n = 24) and CLAR Type II (n = 22) mutations. Significance was determined using DESeq2 Wald Test. Right Panel: Pearson correlation between IL1A mRNA and JAK2V617F allele burden in MPN. Two-tailed t-test was performed for correlation analysis. b Left Panel: Expression levels of IL1B mRNA in granulocytes of heathy controls (HC) (n = 23) and MPN patients with JAK2V617F (n = 62), CLAR Type I (n = 24) and CLAR Type II (n = 22) mutations. Significance was determined using Wald Test. Right Panel: Pearson correlation between IL1B mRNA and JAK2V617F allele burden in MPN. Analysis of publicly available MPN RNA-seq dataset²¹. c IL-1α level in the plasma of healthy controls (n = 11) and patients with PV (n = 18) and MF (n = 10). d IL-1β level in the plasma of healthy controls (n = 11) and patients with PV (n = 17) and MF (n = 16). e IL-1α level in the serum of WT control (n = 6), heterozygous Jak2V617F (Jak2^VF/+) (n = 7) and homozygous Jak2V617F (Jak2^VF/VF) (n = 13) mice. f IL-1β level in the serum of WT (control) (n = 8), heterozygous Jak2V617F (Jak2^VF/+) (n = 9) and homozygous Jak2V617F (Jak2^VF/VF) (n = 20) mice. Data are presented as mean ± SEM. Significance was determined in c–f using one-way ANOVA with Tukey’s multiple comparison test. Source data are provided as a Source Data file.