Table 2.
Survival analysis for the ELSA Study
| HR | 95% CI | p-value | Harrell’s C-index (95% CI) | |
|---|---|---|---|---|
| MPI, 0.10 increase | 1.77 | 1.68–1.87 | < 0.0001 | 80.8 (79.6–81.9)* |
| Sex, males vs. females | 2.21 | 1.97–2.48 | < 0.0001 | |
| Age, 5 years increase | 1.36 | 1.30–1.43 | < 0.0001 | |
| Education > 11 vs. ≤ 11 years of schooling | 0.79 | 0.68–0.91 | 0.0009 | |
| Marital status, married vs. not married | 1.12 | 0.99–1.27 | 0.0767 | |
| Present smoker vs. ex- or never | 1.83 | 1.57–2.13 | < 0.0001 | |
| MPI, risk group | 79.6 (78.4–80.8)** | |||
| Moderate vs. Low | 4.27 | 3.55–5.14 | < 0.0001 | |
| Severe vs. Low | 10.3 | 7.88–13.5 | < 0.0001 | |
| Sex, males vs. females | 2.66 | 2.35–3.01 | < 0.0001 | |
| Age, 5 years increase | 1.33 | 1.27–1.40 | < 0.0001 | |
| Education > 11 vs. ≤ 11 years of schooling | 0.82 | 0.71–0.95 | 0.0062 | |
| Marital status, married vs. not married | 0.99 | 0.88–1.12 | 0.9196 | |
| Present smoker vs. ex- or never | 1.80 | 1.54–2.09 | < 0.0001 |
MPI multidimensional prognostic index, HR hazard ratio, 95% CI 95% confidence interval
*Harrell’s C-index for the model with age, sex, education, marital status, smoking status = 76.4 [mean increase on C for the model with also MPI of 4.5 (SE 0.004), p < 0.0001]
**Harrell’s C-index for the model with only age and sex = 75.4 [mean increase on C for the model with age, sex, education, marital status, smoking status and MPI of 3.3 (SE 0.004), p < 0.0001]