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. 2022 Jun 24;127(6):1162–1171. doi: 10.1038/s41416-022-01875-7

Fig. 5. Survival analysis according to TIME types.

Fig. 5

Cause-specific survival according to the four tumour microenvironment types based on PD-L1 and TILs. Kaplan–Meier curves for each type: type I (PD-L1+/TILs+) adaptive immune resistance, type II (PD-L1−/TILs−) immunological ignorance, type III (PD-L1+/TILs−) intrinsic induction, and type IV (PD-L1−/TILs+) tolerance. At the bottom, the table shows the log-rank test between groups. PD-L1 programmed death ligand 1, TILs tumour infiltrating lymphocyte.