Table 2.

The Mendelian randomization (MR) analysis results with regard to causal effect of SLE on TC, LDL, and HDL levels.

Outcome	Method	SNP (n)	β	95% CI	P-value
TC	Weighted median	49	-0.025	-0.036, -0.015	4.42 × 10-6
	Inverse variance weighted	49	-0.028	-0.039, -0.018	2.16 × 10-7
	MR Egger	49	-0.010	-0.039, -0.019	0.494
LDL	Weighted median	49	-0.015	-0.025, -0.005	0.003
	Inverse variance weighted	49	-0.018	-0.027, -0.009	1.39 × 10-4
	MR Egger	49	-0.002	-0.028, 0.023	0.848
HDL	Weighted median	49	-0.013	-0.021, -0.004	0.004
	Inverse variance weighted	49	-0.012	-0.019, -0.004	0.002
	MR Egger	49	-0.004	-0.025, 0.016	0.683

beta (β), a ratio of changes in standard deviations; SLE, systemic lupus erythematosus; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; SNP, single-nucleotide polymorphism; CI, confidence interval.