TABLE 1.
Effects of RAPA‐, MET‐, and RAPA/MET‐treatments in type 2 diabetic NcZ10 mice: Body composition and food intake
| Group | UNT | RAPA | MET | RAPA/MET |
|---|---|---|---|---|
| BW at sacrifice (g) | 42.9 ± 0.8 | 36.0 ± 1.0*** | 44.5 ± 1.2 | 34.6 ± 0.7*** |
| ΔBW 12–28 wks (g) | +8.3 ± 1.0 | −1.3 ± 1.1*** | +5.9 ± 0.7 | −2.3 ± 0.6*** |
| Food intake (kcal/d/kg lean wt) | 343 ± 26 | 418 ± 21 | 393 ± 25 | 385 ± 27 |
| EPI fat Wt. (g) | 1.18 ± 0.10 | 1.18 ± 0.09 | 1.25 ± 0.10 | 1.06 ± 0.07 |
| EPI fat Wt./BW (%) | 2.7 ± 0.2 | 3.3 ± 0.2 | 2.8 ± 0.3 | 3.1 ± 0.1 |
| ING fat Wt. (g) | 0.61 ± 0.09 | 0.27 ± 0.03** | 0.64 ± 0.06 | 0.24 ± 0.03** |
| ING fat Wt./BW (%) | 1.5 ± 0.2 | 0.8 ± 0.1** | 1.4 ± 0.1 | 0.7 ± 0.1** |
| Fat mass (g) by DXA | 15.5 ± 1.2 | 10.1 ± 0.9** | 14.8 ± 0.7 | 8.9 ± 0.5** |
| % Fat by DXA | 34.4 ± 1.8 | 27.1 ± 1.6* | 33.0 ± 1.3 | 24.9 ± 0.6** |
| Lean mass (g) by DXA | 29.5 ± 1.0 | 26.9 ± 0.5 | 30.0 ± 0.8 | 26.8 ± 0.6 |
| % Lean by DXA | 65.6 ± 1.8 | 72.9 ± 1.6* | 67.0 ± 1.3 | 75.0 ± 0.6** |
| Anus/nose length (cm) | 9.7 ± 0.1 | 9.8 ± 0.1 | 9.9 ± 0.1 | 9.6 ± 0.1 |
| BMD (g/cm2) (DXA) | 0.055 ± 0.001 | 0.056 ± 0.001 | 0.057 ± 0.001 | 0.055 ± 0.001 |
Note: Mean ± SE. ANOVA followed by Tukey–Kramer HSD, significant effects indicated for pairwise comparisons of untreated to treated groups: ***p ≤0.0001, **p ≤ 0.01, *p ≤ 0.05. N = 9–10 for BW, ΔBW, EPI Wt., EPI Wt./BW, and Anus/nose length; N = 3–4 for ING Wt., ING Wt./BW, Food Intake, and DXA. Untreated = UNT, RAPA‐treated = RAPA, MET‐treated = MET, RAPA/MET‐treated = RAPA/MET.