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Changes in IEC differentiation during the aging process. Aging results in silencing of the stem cell marker Lgr5, resulting in a reduction in Wnt signaling and iESC regenerative capacity. Notch1‐mediated inhibition of Atoh1 regulates the differentiation of secretory IECs and maintains balanced differentiation of IEC subtypes in healthy human adults. Decreased expression of Notch1 with age results in a corresponding increase of Atoh1 and preferential skewing toward secretory IEC fate
