FIGURE 3.

Both anti‐CD4 and anti‐CD40L mAbs are required for human neural stem cell (hNSC) graft survival. (A) Serial bioluminescent imaging (BLI) detection of transplanted hNSC‐luc⁺/green fluorescent protein (GFP)⁺ in C57BL/6J mice (3.6 × 10⁵ total cells) receiving anti‐CD4 mAb, anti‐CD40L mAb or both mAbs. (B) BLI signal quantification for all mice at all‐time points. Dual mAb treatment resulted in significantly greater persistence of BLI signal. Sample size: n = 5 animals per group. Data presented as mean for BLI measures, error bars omitted for clarity, analysed by linear mixed effects model, ***p < .001. POD, post‐operative day, wk = week