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. 2022 Aug 31;13:905376. doi: 10.3389/fphar.2022.905376

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Copyright © 2022 Shen, Xu, Xu, Zhang, Lin, Li, Zeng, Qiu, Liang, Xiao and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AIM2 is identified as a target of Myr. (A) Volcano plot indicated up-regulated and down-regulated gene (Padj<0.05 and |log₂FC| >1) by RNA sequencing in Myr-treated versus DMSO-treated RA FLSs from 3 patients. (B) Heatmap of the top 20 differentially expressed genes (DEGs). (C) Bubble plot of the top 13 enriched KEGG pathways of DEGs. (D,E) Myr downregulated the gene and protein expression of AIM2 by using RT-qPCR (D) and Western blot (E). Data are presented as the mean ± SD from at least 3 independent experiments. (F) Immunohistochemistry staining was used to measured AIM2 expression in synovial tissues from RA patients and HC subjects. Original magnification, ×200. ^** p < 0.01 versus HC.