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A brief model describing a theoretical mechanism whereby SEN cell-derived EVs transport pro-inflammatory signals to macrophages. SEN cells release more EVs that contain miR-30b-5p. With the uptake of SEN EVs by macrophages, miR-30b-5p is released from EVs and reduces the level of SIRT1, thereby mediating the increase of p65 entry into the nucleus, and then increasing the synthesis of cytokines IL-6 and IL-1β.
