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. 2022 Aug 31;13:980526. doi: 10.3389/fimmu.2022.980526

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Copyright © 2022 Faissner, Heitmann, Plaza-Sirvent, Trendelenburg, Ceylan, Motte, Bessen, Urlaub, Watzl, Overheu, Reinacher-Schick, Hellwig, Pfaender, Schmitz and Gold

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Flow cytometry analysis of T cell populations. (A) peripheral blood mononuclear cells (PBMCs) of Ofatumumab treated MS patients (Ofa) and healthy controls (HC) were collected 4-13 weeks following the third vaccination against SARS-CoV-2 and restimulated with a SARS-CoV-2 peptide pool followed by immunophenotyping via flow cytometry. SARS-CoV-2 peptide stimulated PBMCs showed (B) no altered frequencies of CD3⁺ T cells (p=0.1564) and (C) CD4⁺ T helper cells or (D, E) activated CD4⁺ T helper cells. (F) Frequencies of CD8⁺ T cells were lower in the Ofa group compared to HC (p=0.0676) while (G) activated Tc cells did not differ. Data were analyzed with a two-tailed Mann-Whitney U test. n=10 Ofa, n=9 HC. (A) Created with BioRender.com.