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. 2022 Sep 8;84:104253. doi: 10.1016/j.ebiom.2022.104253

Figure 6.

Figure 6

Effector function of recalled memory CD8+ T cells from people treated in AHI and CHI. (a) Expression of Granzyme B in ex vivo HIV/EBV-specific CD8+ T cells from people treated from AHI and CHI. (b, c, and f) Expression of T-bet (b), perforin (c), and PD-1 (f) in/on HIV/EBV-specific CD8+ T cells 12 days after stimulation. (d) Cytotoxic capacity of day 13 recalled HIV Nef GK10- or EBV- specific CD8+ T cells cultured with autologous CD4+ T cells at an effector/ target ratio of 2. (e) Expression level of PD-1 on day 12 recalled HIV/EBV-specific CD8+ T cells from individuals treated from AHI and CHI. Differences among groups were analyzed by Kruskal-Wallis test (*P< 0.05; **P< 0.01; ***P< 0.001; ****P< 0.0001). Correlations were analyzed by Spearman correlation with the Benjamini-Hochberg procedure for multiple comparisons (FDR < 0.1).