FIGURE 4.

CMC alleviates chronic hepatic inflammation caused by repeated administrations of adenovirus vector in vivo. Ad‐GFP with or without 1.3% (wt/vol, in PBS) CMC in 30 μl total volume of PBS were intrahepatically injected once every 10 days; and the mice were sacrificed at Weeks 4 and 8, respectively (a). The retrieved liver tissues were subjected to H&E staining (b). Representative inflammatory cells are indicated with yellow arrows (×200). The retrieved liver tissues were also subjected to IHC staining with antibodies against CD45 and CD20 (c). Representative positively stained cells are indicated with red arrows (×400) (c). Representative results are shown