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. 2022 Aug 31;13:963049. doi: 10.3389/fimmu.2022.963049

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Copyright © 2022 Zhang, Zhao, Wang, Wu, Wang, Zhang, Song, Chen, Lv and Hou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intramuscular and intradermal injections elicited similar Tfh and GC B cell responses but induced different levels of response. Inguinal and popliteal lymph nodes were sampled at indicated times following immunization to measure the Tfh and GC B response. (A) CD3+CD4+PD1+CXCR5+ Tfh was determined and compared in mice injected with Ad5-EBOV in different doses and routes. (B) CD4+B220+GL7+IgD- GCB was determined and compared in mice injected with Ad5-EBOV in different doses and routes. Data is represented as median with 95% CI. Statistical significance was determined using one-way ANOVA followed by Tukey's multiple comparisons test. n.s indicated no significance.