Table 3.

Radiologic, endoscopic, and histological features in patients with ICI-induced colitis

	Treatment assessment					Evaluation assessment					Response to TCZ
Patient ID	Radiologic findings	Endoscopic findings	Physicians global assessment	Total mayo score	Histologic	Radiologic findings	Endoscopic findings	Physicians global assessment	Total mayo score	Histologic
C1	Bowel wall thickening (ascending, transverse, descending colon, and sigmoid)	Normal findings	Mild	4	Severe intraepithelial lymphocytosis; mild cryptitis, apoptosis, moderate chronic inflammation in lamina propria; increased subepithelial collagenous band	Unchanged in ascending and transverse colon, slightly increased in the descending colon and sigmoid	Mild irritation	Mild	3	Mild intraepithelial lymphocytosis ↓;mild cryptitis, apoptosis, mild chronic inflammation in lamina propria ↓; normal subepithelial collagenous band ↓	Yes
C2	Bowel wall thickening (rectum)	Edema, redness, pus, erosions from coecum to anal	Severe	10	Ulcerations; diffuse cryptitis and crypt abscesses; severe acute and chronic inflammation in lamina propria; crypt destructions; altered crypt architecture	Reduced bowel wall thickening (rectum)	Decreased redness and edema (rectosigmoid junction and rectum)	Mild	2	No ulcerations; focal cryptitis and crypt abscesses↓; mild acute and chronic inflammation in lamina propria ↓; altered crypt architecture ↔	No, glucocorticoids indicated before evaluation
C9	Bowel wall thickening (pancolitis)	Edema and minor blood extractions,	Mild	4	Cryptitis, crypt abscesses; intraepithelial lymphocytosis; apoptosis; increased amount of plasma cells and eosinophils in lamina propria	No signs of inflammation	Entire colon with edema and vulnerable mucosa	Mild	2	No cryptitis↓; no crypt abscesses; no intraepithelial lymphocytosis %; apoptosis ↔; increased amount of plasma cells and eosinophils in lamina propria ↔	Yes
AC12	NE	Normal	Normal	1	Edema; intraepithelial lymphocytosis; increased amount of plasma cells and eosinophils in lamina propria	NE	Normal	Normal	0	No edema; focal intraepithelial lymphocytosis ↓; mild chronic inflammation in lamina propria ↓	Yes*
C14	Bowel wall thickening (pancolitis)	Edema (general)	Mild	4	Erosions; cryptitis, crypt abscesses; apoptosis; moderate chronic inflammation with eosinophilia in lamina propria	No signs of colitis	Normal	Normal	0	No erosions; no cryptitis or crypt abscesses; no apoptosis; mild chronic inflammation in lamina propria ↓	Yes*
C15	Bowel wall thickening (rectosigmoid colon)	Edema rectosigmoid colon	Moderate	6	Ulceration; cryptitis, crypt abscesses; moderate chronic inflammation with eosinophilia in lamina propria	Reduced bowel wall thickening (rectum)	Normal	Mild	3	No ulceration; no cryptitis or crypt abscesses; mild chronic inflammation with eosinophilia in lamina propria↓	Yes†, but experienced relapse during ICIs. Control after initiation of glucocorticoids
C17	Bowell wall thickening (pyloric partly gastric ventricle, duodenum, jejunum, and rectum)	Normal	Normal	3	Intraepithelial lymphocytosis; chronic inflammation in lamina propria	Increased wall thickening (pyloric part of the gastric ventricle, small intestine, and rectum)	Normal	Normal	3	Normal mucosa; no intraepithelial lymphocytosis; no inflammation	No, stable symptoms. Control during budesonide
C18	Bowel wall thickening (ascending colon, sigmoid, and rectum)	Normal	Normal	2	Edema; mild eosinophil inflammation	Reduced stranding and bowel wall thickening (ascending colon, sigmoid, and rectum)	Normal	Normal	1	Normal mucosa; no edema; no inflammation	Yes, single dose methylprednisolone due to a treatment-related reaction
C19	Bowel wall thickening (sigmoid and descending colon)	Normal	Mild	4	Severe intraepithelial lymphocytosis; cryptitis; apoptosis; severe eosinophil inflammation in lamina propria	Reduced bowel wall thickening (descending colon)	Diffuse hyperemia (colon and rectum)	Mild	2	Mild intraepithelial lymphocytosis ↓; cryptitis ↔; apoptosis ↔; mild eosinophil inflammation in lamina propria ↓	Yes*
AC20	No signs of colitis	Edema in the left side of the colon	Mild	3	Edema; apoptosis; moderate eosinophil inflammation	No signs of colitis	Normal	Normal	0	No edema; no apoptosis; no inflammation	Yes

The arrows indicate the following: ↔, stable/no change; ↑increased, and ↓decrease.

*A second evaluation with colonoscopy was performed during follow-up and revealed ongoing endoscopic and histologic remission of colitis.

†Endoscopy was performed during glucocorticoid therapy.

A, arthritis; AC, arthritis and colitis; C, colitis; ICI, immune checkpoint inhibitors; NE, Not evaluable; TCZ, Tocilizumab.