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. 2022 Sep 13;10(9):e004643. doi: 10.1136/jitc-2022-004643

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Intratumoral administration of CuMV_TT+MCT forms a depot, enhances inflammation and reduces tumor necrosis. (A) Percentage (%) of CD11b^Hi Ly6G^Hi cells in tumors; each dot represents an individual tumor. (B) Representative FACS plots showing the percentage (%) of CD11b^Hi Ly6G^Hi cells in a tumor. (C) Percentage (%) of CD11b^Hi Ly6C^Hi cells in tumors; each dot represents an individual tumor. (D) Representative FACS plots showing the percentage (%) of CD11b^Hi Ly6C^Hi cells in a tumor. (E) Correlation between percentage (%) of CD11b^Hi Ly6G^Hi cells and tumor weight (in mg). (F) Correlation between percentage (%) of CD11b^Hi Ly6C^Hi cells and tumor weight (in mg). (G) Total number of necrosis (mm²); each dot represents an individual tumor. (H) Example of a mock tumor (left): necrosis comprises 30% of the tumor section, example of a treated tumor with the immune-enhancer (right): necrosis comprises 2% of the tumor section. Necrosis is indicated in yellow (*). The entire tumor cross section was assessed for necrosis, H&E staining. Statistical analysis (A, C, G) by Student’s t-test (mean±SEM). Statistical analysis (E, F) by linear regression. n=4 (A–C) and n=5 (E, F, G), one representative of two similar experiments is shown. MCT, microcrystalline tyrosine.