TABLE 3.
Outcomes of liver transplantations in Finland and the US by tertiles of time between brain death and organ procurement (interval).
| Variable | Finland 6/2004–12/2017 | US 1/2008–8/2018 | ||||
|---|---|---|---|---|---|---|
| Tertile of procurement interval | 1st <9.2 h n:214 | 2nd 9.2–12.0 h n:215 | 3rd >12.0 h n:214 | 1st <29.0 h n:19,333 | 2nd 29.0–41.3 h n:19,326 | 3rd >41.3 h n:19,358 |
| Graft survival | ||||||
| 1-year | 92.1% | 90.2% | 92.5% | 87.0% | 88.2% | 89.3% |
| 3-year | 84.6% | 83.1% | 87.8% | 78.5% | 80.3% | 82.5% |
| 5-year | 81.4% | 77.0% | 84.4% | 72.6% | 74.7% | 76.5% |
| 10-year | 74.6% | 64.2% | 77.0% | 57.2% | 61.9% | 58.9% |
| 15-year | 57.2% | 46.4% | 66.0% | NA | NA | NA |
| Intrahepatic biliary stricture | 7 (3.3%) | 13 (6.1%) | 11 (5.2%) | NA | NA | NA |
| Anastomotic biliary stricture | 33 (15.4%) | 27 (12.6%) | 31 (14.5%) | NA | NA | NA |
| Biliary leak | 4 (1.9%) | 7 (3.3%) | 7 (3.3%) | NA | NA | NA |
| Discharge time | NA | NA | NA | 10 (7–18) | 10 (7–18) | 11 (7–19) |
| Early acute rejection a | 44 (20.5%) | 56 (26.2%) | 52 (24.3%) | 1,116 (5.8%) | 1,012 (5.3%) | 970 (5.1%) |
| Acute rejection during first year b | 73 (34.1%) | 84 (39.1%) | 74 (34.6%) | 1,122 (14.4%) | 1,137 (14.6%) | 1,159 (14.8%) |
| MEAF c | 3.3 (2.1–4.6) | 3.3 (2.0–4.5) | 2.9 (1.6–4.1) | NA | NA | NA |
| Post-operative dialysis d | 25 (14.1%) | 30 (16.7%) | 30 (16.5%) | NA | NA | NA |
| Post-operative kidney injury e | 124 (70.5%) | 122 (67.8%) | 121 (66.5%) | NA | NA | NA |
| Difference in creatinine f | 57 (18–131) | 40 (14–121) | 45 (15–113) | NA | NA | NA |
a
In Finnish cohort acute rejection before 30 days and in the US cohort before discharge.
b
For US in sub-cohort of transplantations performed 2013 onwards (middle-tertile of 33–46 h of procurement interval).
c
Model for Early Allograft Function (13), median (interquartile range).
d
AKI requiring dialysis within 7 post-operative days.
e
Acute kidney injury defined by KDIGO guidelines, grades 1–3. 104 patients (16.2%) were dialysed preoperatively and were excluded from post-operative kidney injury and dialysis analysis.
f
Difference between highest creatinine in 7 post-operative days and pretransplantation creatinine in mmol/l.