Supplemental Figure S4.
Differential expression of Slc25 family members and networks by hepatocyte-specific Slc25a34 knockout (Slc-HKO) livers. A: Expression of Slc25 family members. Absolute read count values for each gene were normalized to total read counts obtained per mouse and presented as relative expression of Slc-HKO compared with wild-type (WT) control. B: Ingenuity Pathway Analysis revealed activation of the sterol-responsive element binding protein-1 (SREBP1) network (Srebf1 is the gene encoding SREBP1 protein) in Slc-HKO (Z score, 2.03; P value of overlap 9.0 × 10−3). (C) Ingenuity Pathway Analysis showed inhibition of the peroxisome proliferator-activated receptor α (PPARα) network in Slc-HKO (Z score, –2.90; P value of overlap 3.0 × 10−7). Graphs represent means ± SEM. n = 3 (A). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.