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. 2022 Sep;192(9):1259–1281. doi: 10.1016/j.ajpath.2022.06.002

Figure 7.

Figure 7

Diet-dependent effects on the hepatocyte-specific Slc25a34 knockout (Slc-HKO) liver transcriptome. A and B: Ingenuity Pathway Analysis predictions of canonical pathways (A, Z score less than −2 and >2; and P value of overlap <0.05) and upstream regulators (B, Z score less than −2 and >2; and P value of overlap <0.01) that are activated or inhibited after a short-term fast-food diet (FFD) compared with chow (3-month group). Heatmaps show activity for Slc-HKO versus wild-type (WT) control. (C) Integrated network activity that affects lipid accumulation by Slc-HKO livers on short-term FFD or chow. LPL, lipoprotein lipase; PPARα, peroxisome proliferator-activated receptor α; SIRT1, sirtuin 1; SREBP1, sterol-responsive element binding protein-1; UR, upstream regulator.