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. 2022 Sep 14;13:5378. doi: 10.1038/s41467-022-33080-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Residual viable tumour cell (RVT) ratio, combined positive score (CPS), and radiographic partial response (PR) in 20 patients. The percentage of RVT was evaluated on resected tumour slides after surgery. The CPS was defined as the total number of programmed cell death-ligand 1-stained cells (including tumour cells, tumour-associated lymphocytes, and macrophages) divided by the total number of viable tumour cells plus 100. Radiographic response according to RECIST 1.1 criteria was performed on the basis of imaging examinations before and after neoadjuvant therapy (green triangles for the MPR group [n = 8], black triangles for the non-MPR group [n = 12]). B In the patient who achieved pathological complete response, images of the oral tongue (left) and magnetic resonance imaging (right) before (upper) and after (lower) neoadjuvant therapy are shown. Source data are provided as a Source Data file.