Table 2.

Associations between D0 N-antigen concentration and four clinical outcomes

OR per 500 pg/mL increase (95% CI)	p value
One-week ordinal outcome (n = 252)
Unadjusted
1.05 (1.03–1.07)	< 0.0001
Fully adjusted
1.05 (1.02–1.08)	< 0.0001
ICU admission (n = 168)
Unadjusted
1.08 (1.04–1.12)	< 0.0001
Fully adjusted
1.16 (1.07–1.25)	< 0.0001
28-day mechanical ventilation (n = 221)
Unadjusted
1.04 (1.01–1.06)	0.002
Fully adjusted
1.04 (1.00–1.08)	0.060
28-day mortality (n = 244)
Unadjusted
1.01 (0.98–1.03)	0.63
Fully adjusted
0.98 (0.96–1.01)	0.31

Fully adjusted models include age, sex, body mass index (kg/m²), race, diabetes, hypertension, symptom duration (days), immunosuppression, current smoking status, remdesivir treatment, steroid treatment, baseline 8-point WHO ordinal scale, and date of enrollment. One-week and ICU models include vaccination status. ICU model excludes subjects admitted to the ICU at study enrollment. Mechanical ventilation model excludes subjects who were deceased on day 28