Table 3.

Prognostic accuracy of D0 plasma N-antigen concentration ≥ 1,000 pg/mL for four clinical outcomes

	N-antigen < 1000 pg/mL	N-antigen ≥ 1000 pg/mL	Sensitivity (%)	Specificity (%)	AUROC (95% CI)	PPV (%)	NPV (%)
One-week ordinal status (n = 254)
Stable/Improved	130	90	77	59	0.68 (0.60–0.76)	23	94
Worse	8	27
ICU admission (n = 168)
No ICU	79	49	70	62	0.66 (0.57–0.74)	36	87
ICU	12	28
28-day mechanical ventilation (n = 220)
Alive and free of MV	115	84	59	58	0.58 (0.47–0.69)	13	93
MV	20	25
28-day mortality (n = 244)
Alive	79	49	52	56	0.54 (0.43–0.65)	11	92
Deceased	12	28

AUROC area under the receiver operating curve, MV mechanical ventilation, NPV negative predictive value, PPV positive predictive value